We compared the microscopic and nuclear morphometric characteristics of classical chromophobe renal cell carcinoma (C-ChRC) and renal oncocytoma (RO) and applied meaningful characteristics to differentiate eosinophilic chromophobe renal cell carcinoma (E-ChRC) from RO that has overlapping histology (RO-OH) with E-ChRC to know the usefulness of nuclear morphometry. Microscopic and morphometric characteristics were evaluated in 24 C-ChRCs, 6 E-ChRCs, 5 RO-OHs, and 25 classical ROs (C-ROs). The microscopic findings favoring C-ChRC were rasinoid nuclei, perinuclear halo, and distinct cytoplasmic membrane. Characteristic for C-RO was either stromal edema or hyalinization. The morphometric values of nearest nuclear distance, shortest nuclear diameter, and nuclear diameter ratio were significantly different between C-ChRC and C-RO. However, it was impossible to distinguish E-ChRC from RO-OH by histology and nuclear morphometry. The results of our study show that nuclear morphometry and histomorphology can distinguish between C-ChRC and C-RO but not between E-ChRC and RO-OH.
Written by:
Kim SS, Choi YD, Shim MK, Kim J, Cho YM, Jang JJ, Park RJ, Juhng SW, Choi C Are you the author?
Department of Pathology, Chonnam National University Hwasun Hospital, Chonnam/Chonnam National University Medical School, Gwangju, 501-749, Republic of Korea
Reference: Ann Diagn Pathol. 2012 Apr 9. [Epub ahead of print]
doi: 10.1016/j.anndiagpath.2012.03.002
PubMed Abstract
PMID: 22495123
