Research on prostate cancer progression has focused extensively on the concept of miRNA, which can operate either as promoters or as suppressors of carcinogenesis.
Moreover, recent genetic studies and emerging functional work show that strikingly similar and overlapping pathways are involved in prostate carcinogenesis. Unswervingly, these elements constitute a recently explored 'network of networks' that dynamically reorganizes during DNA damage and is responsible for positively or negatively regulating genome organization and integrity. We consider these facets of convergence and discuss how insights from diametrically opposed interactions of ataxia-telangiectasia mutated and mitrons can inform us about, and possibly help us to get a step closer to personalized medicine.
Written by:
Farooqi AA, Naqi A, Qureshi MZ, Rana A, Khan A, Riaz AM, Afzal SM, Rasheed N, Bhatti S. Are you the author?
Lab for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore, Pakistan.
Reference: Cell Biochem Funct. 2012 Oct;30(7):611-7.
doi: 10.1002/cbf.2847
PubMed Abstract
PMID: 22847890
UroToday.com Investigative Urology Section
