With the aim of identifying novel agents with antigrowth and pro-apoptotic activity on prostate cancer cells, in the present study, we evaluated the effect of a (-)-jasmonic acid derivative, the 3-hydroxy-2(S)-(2Z-butenyl)-cyclopentane-1(S)-acetic acid, obtained by biotransformation, on cell growth in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells.
The results obtained show that the new compound was able to inhibit the growth of both prostate cancer cells. In addition, our data seem to indicate that the apoptosis evocated by this new molecule, at least in part, appears to be associated with an increase of reactive oxygen species (ROS) production.
Written by:
Russo A, Espinoza CL, Caggia S, Garbarino JA, Peña-Cortés H, Carvajal TM, Cardile V. Are you the author?
Department of Drug Sciences, Biochemistry Section, University of Catania, V.le A. Doria 6, 95125 Catania, Italy.
Reference: Cancer Lett. 2012 Dec 30;326(2):199-205.
doi: 10.1016/j.canlet.2012.08.025
PubMed Abstract
PMID: 22935678
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