Biotransformation of 20(S)-protopanaxadiol (1) by the fungus Absidia corymbifera AS 3.3387 yielded five metabolites (2-6).
On the basis of spectroscopic data analyses, the metabolites were identified as 26-hydroxyl-20(S)-protopanaxadiol (2), 23, 24-en-25-hydroxyl-20(S)-protopanaxadiol (3), 25-hydroxyl-20(S)-protopanaxadiol (4), 7β-hydroxyl-20(S)-protopanaxatriol (5), and 7-oxo-20(S)-protopanaxatriol (6), respectively. Among them, 5 and 6 are new compounds. These results indicated that A. corymbifera AS 3.3387 could catalyze the side-chain oxidation-reduction, 7β hydroxylation, and the specific C-7 dehydrogenation of derivatives of 20(S)-protopanaxadiol. The metabolites 2, 5, and 6 showed the more potent inhibitory effects against DU-145 and PC-3 cell lines than the substrate.
Written by:
Chen G, Yang M, Nong S, Yang X, Ling Y, Wang D, Wang X, Zhang W. Are you the author?
School of Medicine, Nantong University, 19 Qi Xiu Road, Nantong 226001, PR China.
Reference: Fitoterapia. 2012 Sep 28;84C:6-10.
doi: 10.1016/j.fitote.2012.09.018
PubMed Abstract
PMID: 23022533
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