BACKGROUND: Prostate cancer (PCa) is a highly prevalent disease in older men of the western world and overall greatly affects the quality of life of elderly people.
AIM: Understanding the mechanism of prostate cancer onset and metastasis is the key to treating this disease successfully and increasing survivability.
MATERIALS AND METHODS: In this study, we constructed crosstalk networks among prostate cancer (primary and metastatic) related pathways by integrating protein-protein interactions (PPI) and KEGG (Kyoto encyclopedia of genes and genomes) pathways information. Total 11 pathways crosstalk with each other in primary prostate cancer and 7 pathways crosstalk with each other in metastatic prostate cancer.
RESULTS: Among these pathways, Notch signaling pathway and chemokine signaling pathway were found regulate multiple processes during prostate cancer progression.
CONCLUSIONS: Results from these studies will provide the groundwork for a combination therapy approach targeting multiple pathways which will likely be more effective than targeting one pathway alone.
Written by:
Wang JM, Wu JT, Sun DK, Zhang P, Wang L. Are you the author?
Department of Urology, Qilu Hospital, Shandong University, Jinan, China.
Reference: Eur Rev Med Pharmacol Sci. 2012 Sep;16(9):1235-42.
PubMed Abstract
PMID: 23047508
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