In the present study, we investigated the roles of TGF-β signaling pathway in a rat benign prostatic hyperplasia (BPH) model treated with cetrorelix.
TGF-β1 and c-Myc expression were measured by qRT-PCR and Western blotting in the proximal and distal region of ventral prostatic lobes, respectively. We observed that treatment with cetrorelix led to a significant reduction of ventral prostate weight in a dose-dependent manner. In the proximal region, after cetrorelix treatment, the expression of TGF-β1 was dramatically increased (P< 0.05), while the expression of c-Myc was significantly decreased (P< 0.05). In comparison with the control group, the cetrorelix groups had more TUNEL-positive cells. Our findings strongly suggest that the TGF-β signaling pathway may be one of the major causes responsible for prostate volume reduction in BPH rats after cetrorelix treatment.
Written by:
Yang D, Hou T, Yang X, Ma Y, Wang L, Li B. Are you the author?
Department of Urology, Huazhong University of Science and Technology, Wuhan, China.
Reference: J Huazhong Univ Sci Technolog Med Sci. 2012 Jun;32(3):389-95.
doi: 10.1007/s11596-012-0067-x
PubMed Abstract
PMID: 22684563
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