Benign prostatic hyperplasia (BPH) is a very frequent age-related proliferative abnormality in men.
Polymorphic CAG repeat in the androgen receptor (AR) can alter transactivation of androgen-responsive genes and potentially influence BPH risk. We investigated the association between CAG repeat length and risk of BPH in a case-control study of a Brazilian population. We evaluated 214 patients; 126 with BPH and 88 healthy controls. DNA was extracted from peripheral leucocytes and the AR gene was analyzed using fragment analysis. Hazard ratio (HR) and 95% confidence interval were estimated using logistic regression models. Mean CAG length was not different between patients with BPH and controls. The CAG repeat length was examined as a categorical variable (CAG ≤ 21 vs. CAG > 21 and CAG ≤ 22 vs. CAG > 22) and did not differ between the control vs. the BPH group. We found no evidence for an association between AR CAG repeat length in BPH risk in a population-based sample of Brazilians.
Written by:
Biolchi V, Silva Neto B, Koff W, Brum IS. Are you the author?
Department of Physiology, Instituto de Ciencias Basicas da Saude Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite 500, Porto Alegre, RS, Brazil.
Reference: Int Braz J Urol. 2012 May-Jun;38(3):373-9.
PubMed Abstract
PMID: 22765868
UroToday.com Investigative Urology Section
