Objective: To explore the anti-tumor effects of asiatic moonseed rhizome extraction-dauricine on bladder cancer EJ cell strain, prostate cancer PC-3Mcell strain and primary cell culture system.
Methods: The main effective component-phenolic alkaloids ofMenispermum dauricum was extracted and separated from asiatic moonseed rhizome by chemical method. MTT method was used to detect dauricine anti-tumor effect.
Results: Dauricine had an obvious proliferation inhibition effect on the main tumor cells in urinary system. The minimum drug sensitivity concentration was between 3.81-5.15 μg/mL, and the inhibition ratio increased with the increase of concentration.
Conclusions: Dauricine, the main effective component extracted from asiatic moonseed rhizome, had a good inhibition effect on tumor cells in urinary system. At the same time, Dauricine has certain inhibition effects on the primary cultured tumor cell.
Written by:
Wang J, Li Y, Zu XB, Chen MF, Qi L Are you the author?
Department of Urology, Xiangya Hospital, Central South University, Changsha Hunan Province, China
Reference: Asian Pac J Trop Med. 2012 Dec;5(12):973-6
doi: 10.1016/S1995-7645(12)60185-0
PubMed Abstract
PMID: 23199717
