Herein, murine prostate cancer cell lines, generated via selective transduction with a single oncogene (c-Myc, Ha-Ras, and v-Src), showed oncogene-specific prostate cancer molecular signatures that were recapitulated in human prostate cancer and developed lung metastasis in immune-competent mice.
Interrogation of two independent retrospective cohorts of patient samples using the oncogene signature showed an ability to distinguish tumor from normal prostate with a predictive value for prostate cancer of 98% to 99%. In a blinded study, the signature algorithm showed independent substratification of reduced recurrence-free survival by Kaplan-Meier analysis. The generation of new oncogene-specific prostate cancer cell lines that recapitulate human prostate cancer gene expression, which metastasize in immune-competent mice, are a valuable new resource for testing targeted therapy, whereas the molecular signatures identified herein provides further value over current gene signature markers of prediction and outcome. Cancer Res; 73(2); 978-89.
Written by:
Ju X, Ertel A, Casimiro MC, Yu Z, Meng H, McCue PA, Walters R, Fortina P, Lisanti MP, Pestell RG Are you the author?
Authors' Affiliations: Departments of Cancer Biology, Stem Cell and Regenerative Medicine, and Pathology, Thomas Jefferson University; and Kimmel Cancer Center, Philadelphia, Pennsylvania
Reference: Cancer Res. 2013 Jan 15;73(2):978-89
doi: 10.1158/0008-5472.CAN-12-2133
PubMed Abstract
PMID: 23204233
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