As we know, prostate cancer down-regulates expression of HLA-1 Antigen Processing Machinery (APM) and has defects in the antigen presentation pathway.
In vitro, the prostate cancer cell (PC-3 cells) infected with Lentivirus TAP1 can efficiently over-express TAP1 and Tapasin, and HLA-1 was also up-regulated on the surface of the infected cells. The lentivirus TAP1 infection increased the apoptosis rate of PC-3 cells. In addition, with the co-cluture PC-3 cells and lymphocytes, TAP1 augmented the expression of CD3⁺CD8⁺CD38⁺ T cell. Importantly, administration of Lentivirus TAP1 to prostate cancer cells in a xenograft mouse model can prolong survival and increase the CD4⁺ T cells, and CD8⁺ T cells as well as decrease Foxp3⁺ T cells in the tumor microenvironment. In summary, a recombinant lentivirus expressing TAP1 can effectively increase prostate cancer tumor-specific immune response.
Written by:
Qiu T, Wang L, Liu XH, Weng XD, Kuang YL, Chen ZY, Chen H, Zhu HC. Are you the author?
Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Reference: Cell Immunol. 2012 Oct;279(2):167-73
doi: 10.1016/j.cellimm.2012.10.004
PubMed Abstract
PMID: 23246678
