African American men (AAM) demonstrate increased prostate cancer incidence and mortality rates.
We investigated known prostate cancer risk factors in AAM. Prostate specific antigen (PSA) and diagnosis of high grade prostatic intraepithelial neoplasia (PIN) were significant prostate cancer predictors. However, even including AAM with low PSA (<4ng/ml), those with PIN had significantly elevated risk, compared to men without PIN (83.3% vs. 6.9%, p<0.0001). In AAM diagnosed with PIN, PSA level was no longer significant (83.3% vs. 92.3%, p=0.593 respectively). Our results suggest that a history of PIN is highly predictive of prostate cancer in AAM, and help provide PSA-independent venues for screening.
Written by:
Chornokur G, Han G, Tanner R, Lin HY, Green BL, Pow-Sang J, Phelan CM. Are you the author?
Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa FL33612, USA.
Reference: Cancer Lett. 2012 Dec 23. pii: S0304-3835(12)00731-8(Epub ahead of print)
doi: 10.1016/j.canlet.2012.12.014
PubMed Abstract
PMID: 23268329
