Prostate-specific membrane antigen (PSMA) overexpression is observed in the neovasculature of solid tumors, but not in the vasculature of normal tissues. Increased PSMA expression is positively associated with tumor stage and grade, although its function in cancer remains unclear.
Mouse double minute 2 (MDM2) is a negative regulator of the p53 tumor suppressor and is reported to regulate VEGF expression and angiogenesis. Both proteins have been considered as biomarkers and therapeutic targets for advanced solid tumors. Our work and a recent microarray-based gene profiling study suggest there could be signaling interplay between MDM2 and PSMA. We herein review the mechanisms underlining the outgrowth of tumors associated with PSMA and MDM2, their potential interaction and how this may be applied to anticancer therapeutics.
Biomarkers in medicine. 2015 Nov 19 [Epub ahead of print]
Robyn Bradbury, Wen G Jiang, Yu-Xin Cui
Cardiff China Medical Research Collaborative, School of Medicine, Cardiff University, UK. , Cardiff China Medical Research Collaborative, School of Medicine, Cardiff University, UK. , Cardiff China Medical Research Collaborative, School of Medicine, Cardiff University, UK.