PURPOSE - Many scientific evidences suggested that the methylation of p16INK4a (p16) was associated with bladder cancer, but some existing studies have yielded inconclusive results about the relationship between p16 promoter methylation and pathological features or the tumor grade of bladder cancer.
This meta-analysis of studies aims to evaluate the clinical and prognostic significance of p16 methylation in bladder carcinogenesis.
MATERIALS AND METHODS - Studies were systemically searched via PubMed and Google Scholar in English up to Sept 2015 and a total of ten appropriate studies (693 cases and 290 controls) with an average NOS score of 6.8 were included. The quality of the appropriate studies was measured by the Newcastle-Ottawa Scale (NOS) assessment.
RESULTS - The meta-analysis results revealed that the methylation state of p16 was statistically significantly associated with an increased risk of bladder cancer (OR=6.71, 95% CI=3.79-11.87) compared to control, and there is no statistically significantly association between the p16 methylation and the tumor pTNM staging (OR=0.59, 95% CI=0.22-1.60) or the tumor grade (OR=1.01, 95% CI=0.52-1.94) in p16 methylated patients compared to unmethylated patients.
CONCLUSIONS - our meta-analysis indicates that p16 promoter methylation may be a promising biomarker for the diagnosis of bladder cancer and the inactivation of p16 may be an early event in bladder carcinogenesis. More studies with larger numbers of participants worldwide are needed to further identify the obvious association above.
International journal of clinical and experimental medicine. 2015 Nov 15*** epublish ***
Defeng Qi, Jinhui Li, Mei Jiang, Chenli Liu, Yuan Hu, Mengxi Li, Jialin Su, Biao Que, Weidong Ji
Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology Kangda Road 1#, Haizhu District, Guangzhou 510230, Guangdong, China., Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology Kangda Road 1#, Haizhu District, Guangzhou 510230, Guangdong, China., Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology Kangda Road 1#, Haizhu District, Guangzhou 510230, Guangdong, China., Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology Kangda Road 1#, Haizhu District, Guangzhou 510230, Guangdong, China., Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology Kangda Road 1#, Haizhu District, Guangzhou 510230, Guangdong, China., Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology Kangda Road 1#, Haizhu District, Guangzhou 510230, Guangdong, China., Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology Kangda Road 1#, Haizhu District, Guangzhou 510230, Guangdong, China., Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology Kangda Road 1#, Haizhu District, Guangzhou 510230, Guangdong, China., The First Affiliated Hospital, Center for Translational Medicine, Sun Yat-sen University Guangzhou, China.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/26884993 Full Text Article