Prostatic urethral transitional cell carcinoma with prostatic invasion in a dog was imaged with abdominal radiography and abdominal ultrasonography antemortem. Synchrotron in-line x-ray phase contrast imaging computed tomography (XPCI-CT) was performed on the prostate ex vivo at the Canadian Light Source Synchrotron and compared to histology.
XPCI-CT imaging provides greater soft tissue contrast than conventional absorption-based x-ray imaging modalities, permitting visualization of regions of inflammatory cell infiltration, differentiation of invasive versus noninvasive tumor regions, and areas of necrosis and mineralization. This represents the first report of XPCI-CT images of an invasive prostatic urothelial neoplasm in a dog.
Journal of medical imaging (Bellingham, Wash.). 2016 Mar 14 [Epub]
James E Montgomery, Michal J Wesolowski, Bailey Wolkowski, Rajni Chibbar, Elisabeth C R Snead, Jaswant Singh, Murray Pettitt, Pritpal S Malhi, Trinita Barboza, Gregg Adams
University of Saskatchewan , College of Medicine, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, Canada., University of Saskatchewan , Department of Medical Imaging, College of Medicine, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, Canada., University of Saskatchewan , Department of Animal and Poultry Science, College of Agriculture and Bioresources, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada., University of Saskatchewan , Department of Pathology and Laboratory Medicine, College of Medicine, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, Canada., University of Saskatchewan , Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada., University of Saskatchewan , Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada., University of Saskatchewan , Department of Animal and Poultry Science, College of Agriculture and Bioresources, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada., Prairie Diagnostic Services , 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada., University of Saskatchewan , Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada., University of Saskatchewan , Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada.