It is known that thyroid hormone is an important regulator of cancer development and metastasis. What is more, changes across the genome, as well as alternative splicing, may affect the activity of the thyroid hormone receptors.
Mechanism of action of the thyroid hormone is different in every cancer; therefore in this review thyroid hormone and its receptor are presented as a regulator of renal cell carcinoma.
Journal of signal transduction. 2016 Mar 13 [Epub]
Łukasz Szymański, Damian Matak, Ewa Bartnik, Cezary Szczylik, Anna M Czarnecka
Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, Warsaw University, Pawinskiego 5a, 02-106 Warsaw, Poland; Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland., Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland; School of Molecular Medicine, Medical University of Warsaw, Zwirki i Wigury 61, 02-091 Warsaw, Poland., Institute of Genetics and Biotechnology, Faculty of Biology, Warsaw University, Pawinskiego 5a, 02-106 Warsaw, Poland; Institute of Biochemistry and Biophysics, Pawinskiego 5a, 02-106 Warsaw, Poland., Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland., Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland.