Aberrant activation of the Wnt/β-catenin pathway and polo-like kinase 1 (Plk1) overexpression represent two common events in prostate cancer with relevant functional implications. This review analyzes their potential therapeutic significance in prostate cancer based on their role as androgen receptor (AR) signalling regulators and the pivotal role of the tumor suppressor protein phosphatase 2A (PP2A) modulating these pathways.
Molecular and cellular biology. 2016 Apr 18 [Epub ahead of print]
Ion Cristóbal, Federico Rojo, Juan Madoz-Gurpide, Jesús García-Foncillas
Translational Oncology Division, Oncohealth Institute, IIS-Fundacion Jimenez Diaz, UAM, University Hospital "Fundacion Jimenez Diaz", Madrid, Spain. Pathology Department, IIS "Fundación Jiménez Diaz", Madrid, Spain., Pathology Department, IIS "Fundación Jiménez Diaz", Madrid, Spain., Translational Oncology Division, Oncohealth Institute, IIS-Fundacion Jimenez Diaz, UAM, University Hospital "Fundacion Jimenez Diaz", Madrid, Spain.