Metabolic rewiring is essential for cancer cell survival. PGC1α, a transcriptional co-activator that is downregulated in prostate cancer, is now shown to control prostate cancer metabolism by activating an oxidative metabolic program that prevents tumour growth and metastatic dissemination.
Nature cell biology. 2016 May 27 [Epub]
Martina Wallace, Christian M Metallo
Department of Bioengineering, University of California, San Diego, La Jolla, California, USA., Department of Bioengineering, University of California, San Diego, La Jolla, California, USA.