In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).
Molecular & cellular oncology. 2015 Apr 18*** epublish ***
María Salazar, Mar Lorente, Elena García-Taboada, Eduardo Pérez Gómez, David Dávila, Patricia Zúñiga-García, Juana M Flores, Antonio Rodríguez, Zoltan Hegedus, David Mosén-Ansorena, Ana M Aransay, Sonia Hernández-Tiedra, Israel López-Valero, Miguel Quintanilla, Cristina Sánchez, Juan L Iovanna, Nelson Dusetti, Manuel Guzmán, Sheila E Francis, Arkaitz Carracedo, Endre Kiss-Toth, Guillermo Velasco
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain., Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain., Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University ; Madrid, Spain., Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre (I+12); Madrid, Spain., Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain., CIC bioGUNE, Bizkaia Technology Park ; Derio, Spain., Department of Animal Surgery and Medicine; School of Veterinary; Complutense University ; Madrid, Spain., Department of Animal Surgery and Medicine; School of Veterinary; Complutense University ; Madrid, Spain., Institute of Biophysics; Hungarian Academy of Sciences ; Szeged, Hungary., CIC bioGUNE, Bizkaia Technology Park ; Derio, Spain., CIC bioGUNE-CIBERehd, Bizkaia Technology Park ; Derio, Spain., Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain., Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain., Instituto de Investigaciones Biomédicas Alberto Sols; Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM) ; Madrid, Spain., Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre (I+12); Madrid, Spain., Centre de Recherche en Carcérologie de Marseille (CRCM); INSERM UMR 1068, CNRS UMR 7258, Aix Marseille Université and Institut Paoli Calmette ; Marseille, France., Centre de Recherche en Carcérologie de Marseille (CRCM); INSERM UMR 1068, CNRS UMR 7258, Aix Marseille Université and Institut Paoli Calmette ; Marseille, France., Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) and Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS); Madrid, Spain., Department of Cardiovascular Science; University of Sheffield ; Sheffield, UK., CIC bioGUNE, Bizkaia Technology Park; Derio, Spain; Ikerbasque, Basque Foundation for Science; Bilbao, Spain; Biochemistry and Molecular Biology Department; University of the Basque Country (UPV/EHU); Bilbao, Spain., Department of Cardiovascular Science; University of Sheffield ; Sheffield, UK., Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.