Prostate cancer which is the second most common cause of death among men has a high incidence in recent years. Current therapeutic regimens should be improved to overcome drug resistance. At the metastatic stage, tumors become refractory to established chemotherapeutic treatments and cause serious problems at the clinics. Development of new drug molecules that are able to transport through the membrane easily and kill tumor cells rapidly is of great interest.
In the current study, a novel Heterodinuclear copper(II)Mn(II) Schiff base complex combined with P85 was used for prostate cancer treatment in vivo. Tramp-C1 cells injected animals were subjected to chemotherapeutic formulation treatment and results were analyzed by toxicology analysis, tumor volume measurements, and histopathological analysis. 0.5 mg/kg Schiff base was selected and combined with 0.05% P85 according to the toxicology analysis showing the enzyme levels, blood parameters, and multiple organ toxicity.
Results demonstrated that Heterodinuclear copper(II)Mn(II) complex-P85 combination decreased tumor formation and tumor volume steadily over the course of experiments.
Overall, Heterodinuclear copper(II)Mn(II) complex-P85 exerted remarkable anti-cancer activity in vivo in C57/B16 mice. Prostate © 2016 Wiley Periodicals, Inc.
The Prostate. 2016 Jun 24 [Epub ahead of print]
Ayşegül Doğan, Selami Demirci, Neşe Başak Türkmen, Ahmet Burak Çağlayan, Safa Aydın, Dilek Telci, Ertuğrul Kılıç, Kazım Şahin, Cemal Orhan, Mehmet Tuzcu, Asiye Işın Doğan Ekici, Fikrettin Şahin
Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey., Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey., Department of Pharmaceutical Toxicology, Inonu University, Malatya, Turkey., Faculty of Medicine, Department of Physiology, Istanbul Medipol University, Istanbul, Turkey., Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey., Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey., Faculty of Medicine, Department of Physiology, Istanbul Medipol University, Istanbul, Turkey., Faculty of Veterinary Medicine, Department of Animal Nutrition, Fırat University, Elazığ, Turkey., Faculty of Veterinary Medicine, Department of Animal Nutrition, Fırat University, Elazığ, Turkey., Faculty of Science, Department of Biology, Fırat University, Elazığ, Turkey., Faculty of Medicine, Department of Pathology, Yeditepe University, Istanbul, Turkey., Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.