Syntheses of androprostamine A (1), and resormycin (3), anti-prostate cancer peptidyl natural products produced by microorganisms, were completed. The characteristic enamide structures of these compounds were installed using the Horner-Wadsworth-Emmons reaction from the corresponding phosphonates in reasonable Z-selectivity.
Chemical & pharmaceutical bulletin. 2016 [Epub]
Hikaru Abe, Yohko Yamazaki, Chiharu Sakashita, Isao Momose, Takumi Watanabe, Masakatsu Shibasaki
Institute of Microbial Chemistry (BIKAKEN), Tokyo.