[CYP1A1 rs4646422 gene polymorphisms not correlated with male infertility in Chinese Han population]

To determine the correlation of the CYP1A1 (rs4646422) gene polymorphisms with male infertility in the Chinese Han population.

Using the Mass ARRAY iPLEX GOLD technique, we conducted a case-control study on theCYPlA1 (rs4646422) gene polymorphisms in 636 infertile males aged 21-49 years (case group) and 442 normal healthy men aged 23-47 years (control group) of the Chinese Han population. We analyzed the genotypes and allele frequencies in the two groups ofsubjects with the SPSS 20.0 software.

Compared with the wild homozygous genotype GG, the heterozygous genotype AG (OR = 1.06, 95% CI 0.81-1.38) and homozygous genotype AA (OR = 1.11, 95% CI 0.56-2.21) showed no correlation with male infertility, nor did the mutant allele A (OR = 1.06, 95% CI 0.85-1.32) in comparison with the wild allele G.

The CYP1A1 (rs4646422) gene polymorphisms might not be correlated with male infertility in the Chinese Han population.

Zhonghua nan ke xue = National journal of andrology. 2016 May [Epub]

Qing Zhou, Pei-ran Zhu, Ming-chao Zhang, Jing Zhang, Wei-jun Jiang, Meng-xia Ni, Shuai-mei Liu, Qiu-yue Wu, Wei-wei Li, Hao-qin Xu, Xin-yi Xia