Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery

Renally cleared zwitterionic nanocarriers (H-Dots) are composed of ε-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and β-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system.

Advanced materials (Deerfield Beach, Fla.). 2016 Jul 14 [Epub ahead of print]

Homan Kang, Julien Gravier, Kai Bao, Hideyuki Wada, Jeong Heon Lee, Yoonji Baek, Georges El Fakhri, Sylvain Gioux, Brian P Rubin, Jean-Luc Coll, Hak Soo Choi

Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA., Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA., Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA., Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA., Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA., Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA., Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA., Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA., Departments of Anatomic Pathology and Cancer Biology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Lerner Research Institute and Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, 44195, USA., Institut Albert Bonniot, Université Grenoble Alpes, Grenoble, F-38000, France., Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.