Prostate cancer (PCa) is one of the most commonly diagnosed cancers in males worldwide. Circular RNA (circRNA) is a unique class of RNA transcribed by RNA polymerase II characterized by jointing 3' and 5' ends together via exon or intron circularization. However, the molecular functions of circRNAs in prostate cancer have rarely been explored. In present study, we found circ-SMARCA5 was up-regulated in prostate cancer samples compared to match normal tissues. We also observed circ-SMARCA5 expression was significantly induced after DHT treatment. Functional experiments showed circ-SMARCA5 acted as an oncogene in prostate cancer by promoting cell cycle and inhibiting cell apoptosis. We thought this study provided useful information for exploring circRNAs as potential therapeutic and prognostic targets for prostate cancer.
Biochemical and biophysical research communications. 2017 Jul 29 [Epub ahead of print]
Zhe Kong, Xuechao Wan, Yalong Zhang, Pu Zhang, Yingyi Zhang, Xiaona Zhang, Xiaoxiang Qi, Hai Wu, Jianfeng Huang, Yao Li
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, PR China., Department of Oncology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, PR China., Shanghai Biotechnology Corporation, Shanghai 201203, PR China; National Engineering Center for Biochip at Shanghai, Shanghai 201203, PR China., Shanghai Biotechnology Corporation, Shanghai 201203, PR China; National Engineering Center for Biochip at Shanghai, Shanghai 201203, PR China. Electronic address: ., State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, PR China. Electronic address: .