Squamous cell carcinoma (SCC) of the urethra is a rare malignancy, comprising less than 1% of all malignancies. The annual age-adjusted incidence of urethral SCC is 4.3 per million in men and 1.5 per million in women. Due to the rarity of the disease, there are a limited number of prospective randomized controlled trials to evaluate the optimal management of locally advanced urethral SCC. Here, we present the case of a 47-year-old man with stage IIIB urethral squamous cell cancer that showed complete clinical and pathologic response to neoadjuvant chemoradiation with only 5-flurouracil after incomplete response to traditional chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP).
Case reports in oncological medicine. 2020 Feb 14*** epublish ***
Krishna H Suthar, Meghana Kesireddy, Mark Sides, Amit Correa, Aijan Ukudeyva, Rohit Venkatesan
Department of Internal Medicine, University of Texas Medical Branch, USA., Department of Internal Medicine, Division of Hematology and Medical Oncology, University of Texas Medical Branch, USA., Department of Pathology, University of Texas Medical Branch, USA., Division of Medical Oncology, MD Anderson Cancer Center, USA.