Due to its rarity and lack of prospective studies, clinical evidence for the management of the inguinal lymphatic nodal basin with radiation therapy in penile cancer (PeCa) has been limited. In this report, we review the current literature and further investigated the landscape of radiation sensitivity in nodal metastases of PeCa utilizing our well-established genome-based radiosensitivity index (RSI) platform. We hypothesized that optimal therapeutic gain could be achieved in PeCa stratified by the combination of clinicopathological parameters, genomic heterogeneity, and RSI-based radiation dose prescription (RxRSI). Similar to primary PeCa lesions, we found that the majority of PeCa nodal metastases are genomically radioresistant with significant heterogeneity. RxRSI should be considered to inform and optimize the radiation therapy dose prescription to the individual tumor biology.
Urologic oncology. 2020 May 29 [Epub ahead of print]
Zhigang Yuan, George Q Yang, Kamran A Ahmed, Javier F Torres-Roca, Philippe E Spiess, Peter A Johnstone
Department of Radiation Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Department of Genitourinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Department of Radiation Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL. Electronic address: .