We report on a 75-year old man who presented with metastatic, squamous-cell carcinoma (SCC) of the penis whose disease had progressed after radiotherapy (RT) and cisplatin-based chemotherapy (CT). A strong PD-L1 expression as well as a CDKN2A mutation was documented, and he was given cemiplimab every 3 weeks at time of disease progression. Complete response (CR) was demonstrated after 10 cycles, and no toxicity was reported. However, this treatment was stopped after 13 cycles when the patient developed moderate severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pneumonitis which required a 2-week hospitalization for oxygen support. Six months later, he remains in CR. To our knowledge, this is the first demonstration of a CR with cemiplimab in a metastatic penile SCC patient previously treated with CT and RT for relapse. Furthermore, the patient remains disease-free despite cemiplimab was withdrawn due to SARS-CoV-2 pneumonitis.
Case reports in oncology. 2021 Jun 21*** epublish ***
Chloé Denis, Sarah Sakalihasan, Pierre Frères, Nadia Withofs, Brieuc Sautois
Department of Medical Oncology, University Hospital of Liege, CHU Sart Tilman, Liège, Belgium., Division of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, University Hospital of Liege, CHU Sart Tilman, Liège, Belgium.