To report surgical, functional and patient reported outcomes(PROs) of glansectomy(GS) and split-thickness skin graft(STSG) reconstruction in case of locally invasive penile cancer(PC) MATERIALS AND METHODS: : A retrospective analysis from May 2015 to August 2019 was conducted.
Inclusion criteria were age<80, a "de novo" malignancy, clinically confined PC (≤T2) with histological confirmation. Complications, recurrence-free(RFS), cancer-free(CFS) and overall survival(OS) were described. Functional outcomes and PRO's were explored using validated questionnaires and "ad hoc" created questionnaire respectively. Kaplan-Meier analysis, t-Student and the Mann-Whitney U test were used to estimate survival and postsurgical functional changes respectively.
34 patients were enrolled. Median follow-up was 12(IQR:12-41) months. Positive surgical margins were detected in 2.9% of cases, requiring salvage surgery.Postoperative complications occurred in 29.4%, most commonly being a graft partial loss(17.6%), meatal stenosis(5.8%) or genital wound infection(5.8%). Disease recurrence occurred in 17.6% of cases with a median elapsed time of 16 months(12-41). 12-month RFS was 88.2%, whilst CSS and OS were 91 % at the same time point. Glans sensation was preserved in 91.2% of cases. 88.2% of patients reported to be fully satisfied with the postoperative aesthetic appearance of the penis, 91.2% of patients would recommend the same procedure to someone else. Limitations include retrospective design and the lack of a control group CONCLUSIONS: : GS with STSG minimizes the impact on urinary and sexual functions without jeopardizing oncological control in locally advanced PC.
Urology. 2022 Jan 14 [Epub ahead of print]
Marco Falcone, Mirko Preto, Gideon Blecher, Massimiliano Timpano, Federica Peretti, Ilaria Ferro, Carlotta Mangione, Paolo Gontero
Urology Clinic - A.O.U. "Città della Salute e della Scienza" - Molinette Hospital, University of Turin, Italy; Neurourology Clinic - A.O.U. "Città della Salute e della Scienza" - Unità Spinale Unipolare, Italy., Urology Clinic - A.O.U. "Città della Salute e della Scienza" - Molinette Hospital, University of Turin, Italy. Electronic address: ., Adjunct Lecturer, Department of Surgery. Monash University. Melbourne (Australia) Wellington Rd, Clayton VIC 3800, Australia; Urology Consultant. Department of Urology, The Alfred Hospital. Melbourne, (Australia) 55 Commercial Rd, Melbourne VIC 3004, Australia., Urology Clinic - A.O.U. "Città della Salute e della Scienza" - Molinette Hospital, University of Turin, Italy.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/35038491