To assess the feasibility, safety, and efficiency of bilateral inguinal lymphadenectomy using simultaneous double laparoscopies for penile cancer.
We reviewed retrospectively the records of 65 patients who underwent inguinal lymph nodes dissection (ILND) for penile cancer from January 2012 to May 2019. Treatments included open ILND (OILND, 19 patients), video-endoscopic inguinal lymphadenectomy (VEIL) using single laparoscopy (S-VEIL, 24 patients), and VEIL using double laparoscopies (D-VEIL, 22 patients). We evaluated the peri-operative and short-term oncological outcomes of the three groups.
The mean operative time of D-VEIL (105.91 ± 10.87 minutes) was significantly shorter than the other two groups, OILND shorter than S-VEIL (160.47 ± 13.74 minutes, 191.67 ± 17.80 minutes, respectively) (P < 0.001). Intraoperative blood loss in the S-VEIL and D-VEIL groups were 53.54 ± 8.78 and 48.41 ± 13.22 ml, respectively; they were significantly lower than that of the OILND group (99.74 ± 9.64 ml; P < 0.001). The numbers of unilateral and total lymph nodes harvested were similar in all groups. The complication rates in the S-VEIL group (4.2%) and the D-VEIL group (4.5%) were significantly lower than that in the OILND group (63.2%; P < 0.001). Compared with open surgery (13.53 ± 1.74 days for hospitalization; 11.37 ± 1.92 days for the left side of drain, 11.95 ± 1.84 days for the right side), the two VEIL groups had significantly shorter drainage tube residence time (7.42 ± 2.02 and 7.32 ± 1.52 days, respectively for the left side; 7.63 ± 1.81 and 7.27 ± 1.58 days, respectively for the right side), shorter postoperative hospitalization (9.46 ± 1.64 and 9.00 ± 1.83 days, respectively) (P < 0.001). There were no statistically significant differences in rates of regional recurrence and short-term survival among the three groups.
Bilateral inguinal lymphadenectomy using double laparoscopies simultaneously can provide adequate oncological outcomes safely and efficiently, and carry significantly lower morbidity than OILND, at a median follow-up of 33.5 months. It is a more time-saving surgical approach for penile cancer patients who need bilateral ILND.
Urologic oncology. 2022 Jan 25 [Epub ahead of print]
Shanjin Ma, Keying Zhang, Ruixiao Li, Jiazhen Lu, Tao Wu, Zhiwei Liu, Xiaoliang Fu, Qisheng Tang, Jianjun Ma
Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Urology, the 955th Hospital of Army, Changdu, Tibet, China., Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China., Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China., Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Urology, Shangluo Central Hospital, Shangluo, Shaanxi, China., Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address: ., Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address: ., Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. Electronic address: .