We aimed to identify prognostic predictive factors of patients with penile squamous cell carcinoma (PSCC). This retrospective study reviewed the clinical and pathological data of patients with PSCC at 10 institutions in Japan between January 2008 and December 2019. The primary endpoint was cancer-specific survival (CSS). We also identified useful predictive factors for CSS in patients with PSCC. In total, 64 patients with PSCC were enrolled. At the end of the follow-up period, 15 patients (23.4%) died owing to PSCC and six (9.4%) died owing to other causes. The 2- and 3-year CSS rates were 78.9% and 76.6%, respectively. Using the Kaplan-Meier method, the Eastern Cooperative Oncology Group performance status 0, serum albumin levels ≥4.2 g/dL, hemoglobin levels ≥13.2 g/dL, C-reactive protein levels <0.21 mg/dL, clinical T stage ≤2, clinically negative lymph node (LN) status, and tumor size <30 mm were associated with a significantly better CSS. In the multivariate analysis, the clinically positive LN status was a significant predictive factor for CSS in patients with PSCC. Further prospective large-scale and long-term studies are required to validate our findings.
Current oncology (Toronto, Ont.). 2022 Aug 01*** epublish ***
Makoto Kawase, Kimiaki Takagi, Kei Kawada, Takashi Ishida, Masayuki Tomioka, Torai Enomoto, Shota Fujimoto, Tomoki Taniguchi, Hiroki Ito, Koji Kameyama, Toru Yamada, Kota Kawase, Daiki Kato, Manabu Takai, Koji Iinuma, Keita Nakane, Takuya Koie
Department of Urology, Gifu University Graduate School of Medicine, Gifu 5011194, Japan., Department of Urology, Daiyukai Daiichi Hospital, Ichinomiya 4918551, Japan., Department of Urology, Gifu Prefectural General Medical Center, Gifu 5008717, Japan., Department of Urology, Gifu Municipal Hospital, Gifu 5008513, Japan., Department of Urology, Japanese Red Cross Takayama Hospital, Takayama 5068550, Japan., Department of Urology, Matsunami General Hospital, Hashima-gun 5016062, Japan., Department of Urology, Ogaki Municipal Hospital, Ogaki 5038502, Japan., Department of Urology, Chuno Kosei Hospital, Seki 5013802, Japan., Department of Urology, Toyota Memorial Hospital, Toyota 4718513, Japan., Department of Urology, Central Japan International Medical Center, Minokamo 5058510, Japan., Department of Urology, Tokai Central Hospital, Kakamihara 5048601, Japan.