Locally advanced penile squamous cell carcinoma with unresectable inguinal lymph node metastasis has a poor prognosis, and surgical treatment alone offers limited benefits. Effective conversion therapy regimens are urgently needed.
We describe a locally advanced penile squamous cell carcinoma patient with bulky, fixed inguinal lymph node metastasis complicated with genital skin ulcers who underwent inguinal lymph node dissection and achieved a pathological complete response with conversion therapy comprising immunotherapy plus chemotherapy.
For unresectable locally advanced penile squamous cell carcinoma, neoadjuvant immunotherapy combined with chemotherapy is a potential treatment approach. Biomarkers of immunotherapy efficacy need to be explored, and clinical trials are needed to test these strategies.
World journal of clinical cases. 2022 Nov 26 [Epub]
Xiang-Yu Long, Shuang Zhang, Lian-Sha Tang, Xiang Li, Ji-Yan Liu
Department of Oncology, Guang'an People's Hospital, Guang'an 638500, Sichuan Province, China., Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China., Department of Biotherapy, Sichuan University, Chengdu 610041, Sichuan Province, China., Department of Urology, West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China.