The treatment of invasive penile cancer is based on partial or total penectomy and perineal urethrostomy configuration.
The aim of the study is to report surgical and functional outcomes of penile amputation and perineal urethrostomy configuration in a consecutive series of patients with invasive penile cancer.
A single-centre retrospective analysis was conducted from January 2018 to December 2022. Data were extracted from clinical records and operative notes. As primary outcomes, surgical complications were described. Oncological outcomes through cancer-specific survival (CSS) and overall survival (OS) were analyzed. Patient survival was estimated by a Kaplan-Meier analysis. Functional outcomes were assessed through the administration of IPSS questionnaire at 3 months follow-up.
Overall 10 patients were enrolled. Median follow-up was 16 months (IQR 12-18). Median age was 71 years (IQR 63-79). Operative time was set at 195 minutes (IQR 155-275). Median hospital stay was 8 days (IQR: 6-10). Postoperative complications occurred in 20% of patients, in one case surgical revision was necessary. Positive surgical margins were detected only in one patient. Median catheterization time was 15 days (IQR: 15-32). 1 patient developed local recurrence. At 1 year the CSS was 80% and OS was 60%. Median preoperative IPSS was 15 (IQR 12-19). Median postoperative IPSS was 6 (IQR 5-7).
Penile amputation and perineal urethrostomy configuration demonstrated to be a safe and effective procedure to address invasive penile cancer.
Urology. 2023 Apr 19 [Epub ahead of print]
Marco Falcone, Mirko Preto, Ilaria Ferro, Lorenzo Cirigliano, Federica Peretti, Plamadeala Natalia, Martina Scavone, Federico Lavagno, Marco Oderda, Paolo Gontero
Department of Urology - "A.O.U. Città della Salute e della Scienza" - Corso Bramante 88 10126 - Turin, Italy., Department of Urology - "A.O.U. Città della Salute e della Scienza" - Corso Bramante 88 10126 - Turin, Italy. Electronic address: .
PubMed http://www.ncbi.nlm.nih.gov/pubmed/37085051