Penile squamous cell carcinoma (PSCC) is a rare malignancy with poor outcomes in advanced stages, with dismal response and survival rates using conventional surgical and systemic options. Additionally, the ability to detect and monitor residual disease with current imaging modalities remains difficult. Therefore, advances in multimodal management and disease monitoring are desperately needed. We present a case of advanced PSCC utilizing multimodal management informed by next generation sequencing and circulating tumor DNA monitoring. These genomic techniques were valuable in guiding management and deserve further evaluation in the management of PSCC and other rare malignancies.
Urology. 2023 Dec 04 [Epub ahead of print]
Levi C Holland, Thomas S Gerald, Bailey Brooks, Vitaly Margulis
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX., Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address: .