Penile cancer (PC), although rare, poses significant challenges in both diagnosis and treatment. Penile squamous cell carcinoma (PSCC) represents the most common histologic subtype of PC, accounting for approximately 95% of cases. With limited therapeutic options available, systemic therapies have emerged as critical components in the management of advanced PSCC. Recent developments in clinical research have revealed the effectiveness of new therapeutic strategies. By elucidating the mechanism of action and clinical evidence supporting these treatments, we strive to offer insights into optimizing treatment strategies and enhancing the quality of care for patients affected by this complex disease.
The Urologic clinics of North America. 2024 May 18 [Epub]
Chiara Mercinelli, Majd Al Assaad, Houssein Safa, Philippe E Spiess, Jad Chahoud, Andrea Necchi
Department of Medical Oncology, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan 20132, Italy. Electronic address: ., Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 413 East 69th Street, Belfer Research Building, New York, NY 10021, USA., Department of Hematology/Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive Office 12538, Tampa, FL 33612, USA., Department of Medical Oncology, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Via Olgettina 60, Milan 20132, Italy. Electronic address: .