We report the case of a malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma (MFH/UPS) of the penis in a 78-years-old-man who had undergone previous radical prostatectomy, external beam radiation therapy for prostatic adenocarcinoma.
The mass was a 9-cm firm lesion at the base of the penis predominantly composed of malignant spindle cells arranged in sweeping fascicles and storiform pattern. The tumor cells stained for vimentin, beta-smooth muscle actin, S-100, and were negative for keratin, desmin, Melan A, PSA. Despite total penectomy, he developed a local reccurence 4 months after surgery, and died from dissemination 6 months after surgery. This is the 8th case of penile MFH/UPS.
Written by:
Sugiura S, Tatenum T, Sakata R, Tajiri T, Kitami K, Gondo T, Kameda Y. Are you the author?
Department of Urology, Fujisawa City Hospital; Department of Pathology, Fujisawa City Hospital; Department of Pathology, Kanagawa Cancer Center.
Reference: Nihon Hinyokika Gakkai Zasshi. 2013 Nov;104(6):706-11.
PubMed Abstract
PMID: 24564078
Article in Japanese.
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