Disease recurrence occurs frequently after surgical treatment for squamous cell carcinoma of the penis (SCCp).
We sought to determine prognostic factors that influence cancer-specific mortality (CSM) after disease recurrence in patients with SCCp. We performed a retrospective analysis of 314 patients who experienced disease recurrence after surgical treatment for SCCp between 1949 and 2012. Competing risk regression analysis addressed factors associated with CSM after SCCp recurrence. Median time from surgery to disease recurrence was 10.5 mo (interquartile range [IQR]: 5.9-21.3). Of the recurrences, 165 (53%), 118 (38%), and 31 (9.9%) were local, regional, or distant, respectively. Within a median follow-up of 4.5 yr (IQR: 2.0-6.5), 108 patients died of SCCp and 41 patients died of causes other than SCCp. Shorter time to disease recurrence was found to be significantly associated with a higher risk of CSM (p=0.0006). Lymph node metastasis at the time of initial treatment (subdistribution hazard ratio [SHR]: 1.96; 95% confidence interval [CI] 1.23- 3.11; p=0.005) and regional recurrence (SHR: 4.14; 95% CI, 2.16-7.93; p< 0.0001) or distant recurrence (SHR: 5.75; 95% CI, 2.59-12.73; p< 0.0001) were associated with increased risk of CSM after disease recurrence. Inclusion of time to recurrence into risk stratification may help patient counseling and treatment planning.
Written by:
Rieken M, Djajadiningrat RS, Kluth LA, Favaretto RL, Xylinas E, Guimaraes GC, Soares FA, Kent M, Sjoberg DD, Horenblas S, Shariat SF. Are you the author?
Department of Urology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, NY, USA; Department of Urology, University Hospital Basel, Basel, Switzerland; Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Urology Service, AC Camargo Cancer Center, São Paulo, Brazil; Department of Urology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, NY, USA; Department of Urology, Cochin Hospital, APHP, Paris Descartes University, Paris, France; Pathology Service, AC Camargo Cancer Center, São Paulo, Brazil; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Department of Urology, Medical University of Vienna, Vienna, Austria.
Reference: Eur Urol. 2014 Jun 9. pii: S0302-2838(14)00492-8.
doi: 10.1016/j.eururo.2014.05.032
PubMed Abstract
PMID: 24924553
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