We report on a rare case of an adult with severe hypercalcemia secondary to the ectopic secretion of parathyroid-related peptide (PTH-rP) from a penile squamous cell cancer (PC).
A patient of 47 years old was admitted with warty lesions and areas of ulceration covered by purulent material in a large area of the groin, scrotum and penis. Laboratory tests revealed severe hypercalcemia and elevation of PTH-rP; the biopsy reported PC. Hypercalcemia was successfully treated with zoledronic acid, however, the tumor displayed aggressive behavior, which resulted in a poor prognosis for the patient.
Written by:
Trejo-Rosales R, Nevarez-Barragan MJ, Rosas-Jurado MG, Perez-Diaz I, Bezaury AP. Are you the author?
Division of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion ?Salvador Zubiran?, Mexico City, Mexico; Instituto Tecnologico y de Estudios Superiores de Monterrey, Mexico City, Mexico; Unidad PET/CT, Facultad de Medicina, UNAM, Mexico City, Mexico.
Reference: Arq Bras Endocrinol Metabol. 2014 Aug;58(6):646-9.
doi: 10.1590/0004-2730000002880
PubMed Abstract
PMID: 25211448