BACKGROUND: Human papillomavirus (HPV) causes external genital lesions (EGLs) in men, including condyloma and penile intraepithelial neoplasia (PeIN). We sought to determine incidence, HPV genotype distribution, and differences by age and lesion type among men.
METHODS: HIM Study participants who contributed ≥2 visits from 2009-2013 were included in the biopsy cohort. INNO-LiPA genotyping was performed on all pathologically confirmed EGLs. Age-specific analyses were conducted for incident EGLs, with Kaplan-Meier estimation of cumulative incidence.
RESULTS: This biopsy cohort included 2,754 men (median follow-up: 12.4 months, IQR: 6.9-19.2). EGLs (N=377) were pathologically confirmed in 228 men, 198 of whom had incident EGLs. Cumulative incidence of any EGL was highest among men < 45 years old and decreased significantly over time with age for condyloma. Genotype-specific incidence varied by pathological diagnoses, with high- and low-risk genotypes found in 15.6% and 73.2% of EGLs, respectively. Condyloma primarily contained HPV 6 or 11. While PeIN lesions primarily contained HPV 16, one PeIN III lesion was positive for HPV 6 only.
CONCLUSION: Low- and high-risk HPV genotypes contribute to the EGL burden. Men remain susceptible to HPV-related EGLs throughout the lifespan, making it necessary to ensure longevity of immune protection against the most commonly causative HPV genotypes.
Written by:
Ingles DJ, Pierce Campbell CM, Messina JA, Stoler MH, Lin HY, Fulp WJ, Abrahamsen M, Sirak BA, O'Keefe MT, Papenfuss M, Gage C, da Silva RC, Sosa RG, Juarez OR, Villa LL, Ponce EL, Giuliano AR. Are you the author?
Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA; University of Virginia School of Medicine, Charlottesville, VA, USA; University of São Paulo School of Medicine, São Paulo, Brazil; Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
Reference: J Infect Dis. 2014 Oct 24. pii: jiu587.
doi: 10.1093/infdis/jiu587
PubMed Abstract
PMID: 25344518
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