OBJECTIVE - The association between pre-treatment levels of C-reactive protein (CRP) and squamous cell carcinoma antigen (SCC-Ag) has not been clarified. Therefore, we evaluated the relevance of CRP and SCC-Ag levels in relation to clinicopathologic factors and prognosis in penile cancer.
PATIENTS AND METHODS - A total of 124 Chinese penile squamous cell cancer patients treated between November 2007 and October 2014 were analyzed retrospectively. Receiver operating characteristic curves were used to identify the combination of markers with the best sensitivity and specificity for prognosis prediction. Statistical data analysis was performed using a nonparametric method, and survival analysis was performed using the log rank test and Cox proportional hazard model.
RESULTS - Levels of CRP ≥4. 5 mg/L and SCC-Ag ≥1. 4 ng/ml were both significantly associated with lymph node metastasis laterality (χ(2) trend test, P=0. 041), extranodal extension (χ(2) trend test, P
CONCLUSIONS - The present study demonstrated that the combined measurement of preoperative CRP and SCC-Ag levels may serve as an independent biomarker for lymph node metastasis, advanced tumor stage and disease-specific survival in penile squamous cell carcinoma patients. This article is protected by copyright. All rights reserved.
BJU international. 2015 Nov 17 [Epub ahead of print]
Zai-Shang Li, Kai Yao, Yong-Hong Li, Jie-Ping Chen, Chuang-Zhong Deng, Qi Zhao, Peng Chen, Bin Wang, Qi-Wu Mi, Zhuo-Wei Liu, Zi-Ke Qin, Hui Han, Fang-Jian Zhou
Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R, China. , Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R, China. , Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R, China. , Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R, China. , Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R, China. , School of Life Science, Sun Yat-sen University, Guangzhou, P. R, China. , Department of Urology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumchi, P. R, China. , Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, P. R, China. , Department of Urology, Dong Guan People's Hospital, Guang Dong, P. R, China. , Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R, China. , Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R, China. , Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R, China. , Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, P. R, China.