OBJECTIVES - To determine the role of Penile Doppler Ultrasound (PDU) compared to Magnetic Resonance Imaging in preoperative diagnostic evaluation of patients with Penile Squamous Cell Carcinoma .
MATERIALS AND METHODS - A prospective analysis on patients presenting with clinical diagnosis of penile squamous cell carcinoma from 6 different European Hospitals between 2012 and 2014 was carried out.
Each patient who had planned a organ sparing approach underwent an MRI and PDU both with an artificial erection with PGE1. Age, evidence of MRI or PDU corpora cavernosa (CC) infiltration, FSE report, definitive pathological report and surgical approach used per patient were recorded. Accuracy, Precision, Negative Predictive Value, Sensitivity and Specificity were calculated. Outcomes were statistically evaluated.
RESULTS - 200 patients were enrolled in the study. The mean age of the patients was 67. 35±15. 45 (range 51-82). All of the patients were treated surgically. Of the 200 patients, 135 (67. 5%) underwent a corpora sparing approach while 65 had a partial penectomy because of the frozen section outcome. About CC infiltration the definitive outcome confirmed the FSE. Penile Doppler US vs MRI Accuracy was 96. 5% vs 90. 5%; Precision 92. 6% vs 96%; Sensitivity 96. 9% vs 73. 8%, Specificity 96. 2% vs 98. 5%. Despite Sensitivity (p<0-05) no statistical evidence was found between US and MRI.
CONCLUSIONS - Penile Doppler US has a statistical similar outcome on detecting infiltration of corpora cavernosa and could be used as a less expensive tool to drive surgical strategy in patient with a diagnosis of penile Squamous Cell Carcinoma.
Urology. 2016 Jan 14 [Epub ahead of print]
G Bozzini, M Provenzano, J Romero Otero, M Margreiter, E Garcia Cruz, B Osmolorskij, P Verze, N Pavan, F Sanguedolce, N Buffi, G Guazzoni, G Taverna
Humanitas Mater Domni, Dept. of Urology, Castellanza, Italy. Humanitas University, Milan, Italy. , Hospital Universitario 12 De Octubre, Dept. of Urology, Madrid, Spain. , Vienna General Hospital, Dept. of Urology, Vienna, Austria. , Hospital Clínic De Barcelona, Dept. of Urology, Barcelona, Spain. , Lomonosov Hospital, Dept. of Urology, Moscow, Russia. , University of Naples Federico II, Dept. of Urology, Naples, Italy. , University of Trieste, Dept. of Urology, Trieste, Italy. , King's College Hospital, Dept. of Urology, London, UK. , Humanitas University, Milan, Italy. , Humanitas University, Milan, Italy. , Humanitas Mater Domni, Dept. of Urology, Castellanza, Italy.