Prostate cancer is one of the most common cancers in men. Recent estimates suggest that over a million men are diagnosed with the disease annually. Prostate cancer pathogenesis involves both heritable and environmental factors. The molecular events involved in the development or progression of prostate cancer are still unclear. Recent body of literature highlights the role of viral infections in initiation or progression of prostate cancer. In this regard, certain viruses have been reported to interact with host proteins and bring about changes in genetic, immunological and inflammatory events that lead to initiation or progression of prostate cancer. We conducted a comprehensive PubMed database search to identify publications relevant to viruses associated with prostate cancer. In this review, we discuss the possible viral etiology of prostate cancer and evidence of viral-mediated genetic changes, and immune dysregulation involved in initiation or progression of prostate cancer.
International journal of surgery (London, England). 2018 Feb 26 [Epub ahead of print]
Syed Hani Abidi, Fareena Bilwani, Kulsoom Ghias, Farhat Abbas
Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan. Electronic address: ., Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan. Electronic address: ., Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan. Electronic address: ., Department of Surgery, Aga Khan University, Stadium Road, Karachi, Pakistan. Electronic address: .