Cooperative oncogenic effects resulting from the loss of PTEN and overexpression of MYC overcome the deleterious effects of endoplasmic reticulum stress not only to promote the growth of aggressive prostate cancer but also to expose a new therapy target for this disease (Nguyen et al, this issue).
Science translational medicine. 2018 May 02 [Epub]
Christopher Logothetis, Ana Aparicio, Timothy C Thompson
Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA. ., Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.