The molecular underpinnings of a prostate-cancer-associated SNP are investigated in a pair of papers in this issue of Cell. Together, Gao et al. and Hua et al. paint a picture of competition between transcription factors that, in turn, toggle the function of a regulatory region from a promoter to an enhancer and induce a switch in noncoding RNA isoforms.
Cell. 2018 Jul 26 [Epub]
Michael Bulger
Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA. Electronic address: .