Whole-pelvis pencil beam scanning (PBS) proton therapy is utilized in both the intact and post-operative settings in patients with prostate cancer. As whole pelvis prostate radiotherapy has traditionally been delivered with standard photon beams, limited evidence and technical descriptions have been reported regarding the use of proton therapy.
Here we present two robust three-field treatment planning approaches utilized to maximize target coverage in the presence of anatomic and delivery uncertainties. Both techniques, conventional optimization (CO) and robust optimization (RO), create treatment plans with acceptable target coverage and sparing of organs at risk (OAR). While the RO method is less time intensive and may theoretically allow for superior OAR sparing and improved robustness, the CO method can be implemented by institutions who do not have RO capabilities.
Medical dosimetry : official journal of the American Association of Medical Dosimetrists. 2020 May 26 [Epub ahead of print]
Anish A Butala, W Scott Ingram, Shannon E O'Reilly, Brett Hartl, Ali Kassaee, Curtiland Deville, Neha Vapiwala
Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Boulevard, TRC-2 West, Philadelphia, Pennsylvania 19104, USA. Electronic address: ., Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Boulevard, TRC-2 West, Philadelphia, Pennsylvania 19104, USA., Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 401 North Broadway, Baltimore, Maryland 21287, USA.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/32471604