The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma

Five years after the last prostatic carcinoma grading consensus conference of the International Society of Urological Pathology (ISUP), accrual of new data and modification of clinical practice require an update of current pathologic grading guidelines. This manuscript summarizes the proceedings of the ISUP consensus meeting for grading of prostatic carcinoma held in September 2019, in Nice, France. Topics brought to consensus included the following: (1) approaches to reporting of Gleason patterns 4 and 5 quantities, and minor/tertiary patterns, (2) an agreement to report the presence of invasive cribriform carcinoma, (3) an agreement to incorporate intraductal carcinoma into grading, and (4) individual versus aggregate grading of systematic and multiparametric magnetic resonance imaging–targeted biopsies. Finally, developments in the field of artificial intelligence in the grading of prostatic carcinoma and future research perspectives were discussed.

Authors: van Leenders, Geert J.L.H. MD^*; van der Kwast, Theodorus H. MD^†; Grignon, David J. MD^‡; Evans, Andrew J. MD^§; Kristiansen, Glen MD^∥; Kweldam, Charlotte F. MD^*; Litjens, Geert PhD^¶; McKenney, Jesse K. MD^#; Melamed, Jonathan MD^**; Mottet, Nicholas MD^{††,‡‡}; Paner, Gladell P. MD^§§; Samaratunga, Hemamali FRCPA^∥∥; Schoots, Ivo G. MD^¶¶; Simko, Jeffry P. MD^##; Tsuzuki, Toyonori MD^***; Varma, Murali MD^†††; Warren, Anne Y. MD, FRCPath^‡‡‡; Wheeler, Thomas M. MD^§§§; Williamson, Sean R. MD^∥∥∥; Iczkowski, Kenneth A. MD^¶¶¶ ISUP Grading Workshop Panel Members

Departments of ^*Pathology

^¶¶Radiology and Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam

^¶Diagnostic Image Analysis Group and the Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands

^†Department of Pathology, Princess Margaret Cancer Center

^§Department of Laboratory Information Support Systems, University Health Network, Toronto, ON, Canada

^‡Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN

^∥Institute of Pathology of the University Hospital Bonn, Bonn, Germany

^#Department of Pathology, Cleveland Clinic, Cleveland, OH

^**Department of Pathology, New York University Langone Medical Center, New York, NY

^††Urology Department, University Hospital

^‡‡Department of Surgery, Jean Monnet University, Saint-Etienne, France

^§§Department of Pathology, University of Chicago, Chicago, IL

^∥∥Department of Pathology, University of Queensland School of Medicine, and Aquesta Uropathology, St Lucia, QLD

^##Department of Pathology, University of California, San Francisco, CA

^***Department of Surgical Pathology, Aichi Medical University, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan

^†††Department of Cellular Pathology, University Hospital of Wales, Cardiff, Wales

^‡‡‡Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

^§§§Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX

^∥∥∥Department of Pathology, Henry Ford Health System and Wayne State University School of Medicine, Detroit, MI

^¶¶¶Department of Pathology, Medical College of Wisconsin, Milwaukee, WI

Source: van Leenders et all. The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma, The American Journal of Surgical Pathology. doi: 10.1097/PAS.0000000000001497.

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