Stereotactic body radiotherapy (SBRT) for prostate cancer (PCa) is gaining interest by the recent publication of the first phase III trials on prostate SBRT and the promising results of many other phase II trials. Before long term results became available, the major concern for implementing SBRT in PCa in daily clinical practice was the potential risk of late genitourinary (GU) and gastrointestinal (GI) toxicity. A number of recently published trials, including late outcome and toxicity data, contributed to the growing evidence for implementation of SBRT for PCa in daily clinical practice. However, there exists substantial variability in delivering SBRT for PCa. The aim of this topical review is to present a number of prospective trials and retrospective analyses of SBRT in the treatment of PCa. We focus on the treatment strategies and techniques used in these trials. In addition, recent literature on a simultaneous integrated boost to the tumor lesion, which could create an additional value in the SBRT treatment of PCa, was described. Furthermore, we discuss the multicenter consensus of the FLAME consortium on SBRT for PCa with a focal boost to the macroscopic intraprostatic tumor nodule(s).
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2019 Jul 02 [Epub]
Cédric Draulans, Robin De Roover, Uulke A van der Heide, Karin Haustermans, Floris Pos, Robert Jan Smeenk, Hans De Boer, Tom Depuydt, Martina Kunze-Busch, Sofie Isebaert, Linda Kerkmeijer
Department of Radiation Oncology, University Hospitals Leuven, Belgium; Department of Oncology, KU Leuven, Belgium. Electronic address: ., Department of Radiation Oncology, University Hospitals Leuven, Belgium; Department of Oncology, KU Leuven, Belgium. Electronic address: ., Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address: ., Department of Radiation Oncology, University Hospitals Leuven, Belgium; Department of Oncology, KU Leuven, Belgium. Electronic address: ., Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address: ., Department of Radiation Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address: ., Department of Radiation Oncology, University Medical Center, Utrecht, The Netherlands. Electronic address: ., Department of Radiation Oncology, University Hospitals Leuven, Belgium; Department of Oncology, KU Leuven, Belgium. Electronic address: ., Department of Radiation Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address: ., Department of Radiation Oncology, University Hospitals Leuven, Belgium; Department of Oncology, KU Leuven, Belgium. Electronic address: ., Department of Radiation Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands; Department of Radiation Oncology, University Medical Center, Utrecht, The Netherlands. Electronic address: .