There remains a paucity of data related to germline genetic alterations predisposing patients to prostate cancer. Recent data suggest that African American, Hispanic, and Asian and Pacific Islander men exhibit genetic alterations in both highly penetrant germline genes, including BRCA1/2, ATM, and CHEK2, and the mismatch repair genes associated with Lynch syndrome, as well as low-penetrant single-nucleotide polymorphisms. However, cohort sizes remain small in many studies limiting the ability to determine clinical significance, appropriate risk stratification, and treatment implications in these diverse populations.
The Urologic clinics of North America. 2021 Jun 12 [Epub]
Kelly K Bree, Patrick J Henley, Curtis A Pettaway
The University of Texas MD Anderson Cancer Center, Department of Urology, 1515 Holcombe Boulevard, Houston, TX 77030, USA., The University of Texas MD Anderson Cancer Center, Department of Urology, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address: .