Androgen deprivation therapy (ADT) alone has been the cornerstone of treatment for patients with newly diagnosed metastatic prostate cancer for the past century. Based on results from landmark trials in the past decade, combination approaches of ADT with chemotherapy or novel hormonal agents have established a new standard of care for these patients.
This paradigm shift in treatment has been reflected in the updates to guideline recommendations of major professional associations. However, real-world data from around the world have highlighted the dismal adoption of combination therapy, despite evidence-based recommendations. The disparity between evidence and practice is concerning, especially with emerging evidence of survival benefit with further treatment intensification using triplet combinations (ADT, docetaxel and novel hormonal agents). Thus, a pressing need to raise awareness and call the uro-oncology community to action exists to deliver evidence-based care for these patients.
Nature reviews. Urology. 2022 Dec 12 [Epub ahead of print]
Kenneth Chen, Jonathan O'Brien, Aoife McVey, Pocharapong Jenjitranant, Brian D Kelly, Veeru Kasivisvanathan, Nathan Lawrentschuk, Declan G Murphy, Arun A Azad
Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Department of Urology, University College London Hospitals Trust, London, UK., Department of Urology, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. ., Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/36509970