The summary presented herein covers recommendations on the early detection of prostate cancer and provides a framework to facilitate clinical decision-making in the implementation of prostate cancer screening, biopsy, and follow-up. This is Part I of a two-part series that focuses on prostate cancer screening. Please refer to Part II for discussion of initial and repeat biopsies as well as biopsy technique.
The systematic review utilized to inform this guideline was conducted by an independent methodological consultant. The systematic review was based on searches in Ovid MEDLINE and Embase and Cochrane Database of Systematic Reviews (January 1, 2000-November 21, 2022). Searches were supplemented by reviewing reference lists of relevant articles. The AUA employs a 3-tiered strength of evidence system to underpin evidence-based guideline statements. The AUA nomenclature system explicitly links statement type to body of evidence strength, level of certainty, magnitude of benefit or risk/burdens, and the Panel's judgment regarding the balance between benefits and risks/burdens.
The Early Detection of Prostate Cancer Panel developed evidence- and consensus-based guideline statements to provide guidance in prostate cancer screening, initial and repeat biopsy, and biopsy technique.
Prostate-specific antigen (PSA)-based prostate cancer screening in combination with shared decision-making (SDM) is recommended. Current data regarding risk from population-based cohorts provide a basis for longer screening intervals and tailored screening, and the use of available online risk calculators is encouraged.
The Journal of urology. 2023 Apr 25 [Epub ahead of print]
John T Wei, Daniel Barocas, Sigrid Carlsson, Fergus Coakley, Scott Eggener, Ruth Etzioni, Samson W Fine, Misop Han, Sennett K Kim, Erin Kirkby, Badrinath R Konety, Martin Miner, Kelvin Moses, Merel G Nissenberg, Peter A Pinto, Simpa S Salami, Lesley Souter, Ian M Thompson, Daniel W Lin
University of Michigan, Ann Arbor, Michigan., Vanderbilt University, Nashville, Tennessee., Memorial Sloan Kettering Cancer Center, New York, New York., Oregon Health and Science University, Portland, Oregon., University of Chicago, Chicago, Illinois., Fred Hutchinson Cancer Center, Seattle, Washington., Johns Hopkins University, Baltimore, Maryland., American Urological Association, Linthicum, Maryland., Allina Health., Brown University, Providence, Rhode Island., National Alliance of State Prostate Cancer Coalitions., National Institutes of Health, Bethesda, Maryland., Nomadic EBM Methodology., CHRISTUS Health., University of Washington, Seattle, Washington.