To evaluate the association between ejaculation frequency (EF) during four stages of life and prostate cancer (PCa) according to tumor aggressiveness, PCa stage, and urinary symptomatology.
A total of 456 incident PCa cases histologically confirmed, and 427 controls aged 40-80 years from the CAPLIFE study were analyzed. This study is a population-based case-control study carried out in the south of Spain. Average EF was measured for: (1) 20s, (2) 30s, (3) 40s, and (4) one year before the interview. EF was categorized into: (1) 0-3, (2) 4, and (3) >4 ejaculations/month. Sociodemographic, lifestyle, and medical information were also collected. To estimate the association between EF and PCa, adjusted ORs (aORs) and 95% CIs were calculated by logistic regression models.
A year before the interview, PCa cases ejaculated less frequently than the controls. An inverse association was observed between the EF a year before and PCa, aOR=1.64 (95% CI 1.03-2.61) for men with 4 ejaculations/month, and aOR=2.38 (95% CI 1.57-3.60) for men with 0-3 ejaculations/month, compared to men with >4. The association was higher for cases with ISUP 3-5 (aOR=2.76 [95% CI 1.34-5.67] for men with 0-3 ejaculations/month) or with a locally advanced-metastatic tumor (aOR=4.70 [95% CI 1.55-14.29]). Moreover, men with moderate urinary symptoms and 0-3 ejaculations/month had the highest risk, aOR=3.83 (95% CI 1.84-7.95).
A low EF could be associated with a higher risk of PCa, especially for cases with ISUP 3-5 or with a locally advanced-metastatic tumor.
The world journal of men's health. 2023 Mar 27 [Epub ahead of print]
Macarena Lozano-Lorca, Rocío Olmedo-Requena, Rocío Barrios-Rodríguez, Antonio Jiménez-Pacheco, Fernando Vázquez-Alonso, Helga-María Castillo-Bueno, Miguel Rodríguez-Barranco, José Juan Jiménez-Moleón
Departamento de Enfermería, Faculty of Health Sciences of Ceuta, Universidad de Granada, Ceuta, Spain., Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain., Department of Urology, Clínico San Cecilio University Hospital, Granada, Spain., Department of Urology, Virgen de las Nieves University Hospital, Granada, Spain., Maracena Primary Health Care Centre, Distrito Sanitario Granada-Metropolitano, Granada, Spain.