The purpose of this study was to develop and test across various scanners a zone-specific region-of-interest (ROI)-based computer-aided diagnosis system (CAD) aimed at characterizing, on MRI, International Society of Urological Pathology (ISUP) grade≥2 prostate cancers.
ROI-based quantitative models were selected in multi-vendor training (265 pre-prostatectomy MRIs) and pre-test (112 pre-biopsy MRIs) datasets. The best peripheral and transition zone models were combined and retrospectively assessed in internal (158 pre-biopsy MRIs) and external (104 pre-biopsy MRIs) test datasets. Two radiologists (R1/R2) retrospectively delineated the lesions targeted at biopsy in test datasets. The CAD area under the receiver operating characteristic curve (AUC) for characterizing ISUP≥2 cancers was compared to that of the Prostate Imaging-Reporting and Data System version2 (PI-RADSv2) score prospectively assigned to targeted lesions.
The best models used the 25th apparent diffusion coefficient (ADC) percentile in transition zone and the 2nd ADC percentile and normalized wash-in rate in peripheral zone. The PI-RADSv2 AUCs were 82% (95% confidence interval [CI]: 74-87) and 86% (95% CI: 81-91) in the internal and external test datasets respectively. They were not different from the CAD AUCs obtained with R1 and R2 delineations, in the internal (82% [95% CI: 76-89], P = 0.95 and 85% [95% CI: 78-91], P = 0.55) and external (82% [95% CI: 74-91], P = 0.41 and 86% [95% CI:78-95], P = 0.98) test datasets. The CAD yielded sensitivities of 86-89% and 90-91%, and specificities of 64-65% and 69-75% in the internal and external test datasets respectively.
The CAD performance for characterizing ISUP grade≥2 prostate cancers on MRI is not different from that of PI-RADSv2 score across two test datasets.
Diagnostic and interventional imaging. 2023 May 17 [Epub ahead of print]
Tristan Jaouen, Rémi Souchon, Paul C Moldovan, Flavie Bratan, Audrey Duran, Au Hoang-Dinh, Florian Di Franco, Sabine Debeer, Marine Dubreuil-Chambardel, Nicolas Arfi, Alain Ruffion, Marc Colombel, Sébastien Crouzet, Christelle Gonindard-Melodelima, Olivier Rouvière
INSERM, LabTAU, U1032, Lyon, 69003, France., Hospices Civils de Lyon, Hôpital Edouard Herriot, Department of Vascular and Urinary Imaging, Lyon, 69003, France., Hôpital Saint Joseph Saint Luc, Department of Radiology, Lyon, 69007, France., Univ Lyon, CNRS, Inserm, INSA Lyon, UCBL, CREATIS, UMR5220, U1294, Villeurbanne, 69100, France., INSERM, LabTAU, U1032, Lyon, 69003, France; Hanoi Medical University, Department of Radiology, Hanoi, 116001, Vietnam., Hôpital Saint Joseph Saint Luc, Department of Urology, Lyon, 69007, France., Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Department of Urology, Pierre-Bénite, 69310, France; Equipe 2 - Centre d'Innovation en Cancérologie de Lyon (EA 3738 CICLY), Pierre-Bénite, 69310, France; Université de Lyon, Lyon, 69003, France; Université Lyon 1, Lyon, 69003, France; Faculté de Médecine Lyon Sud, Pierre-Bénite, 69310, France., Université de Lyon, Lyon, 69003, France; Université Lyon 1, Lyon, 69003, France; Hospices Civils de Lyon, Hôpital Edouard Herriot, Department of Urology, Lyon, 69003, France; Faculté de Médecine Lyon Est, Lyon, 69003, France., INSERM, LabTAU, U1032, Lyon, 69003, France; Université de Lyon, Lyon, 69003, France; Université Lyon 1, Lyon, 69003, France; Hospices Civils de Lyon, Hôpital Edouard Herriot, Department of Urology, Lyon, 69003, France; Faculté de Médecine Lyon Est, Lyon, 69003, France., Université Grenoble Alpes, Laboratoire d'Ecologie Alpine, BP 53, Grenoble 38041, France; CNRS, UMR 5553, BP 53, Grenoble, 38041, France., INSERM, LabTAU, U1032, Lyon, 69003, France; Hospices Civils de Lyon, Hôpital Edouard Herriot, Department of Vascular and Urinary Imaging, Lyon, 69003, France; Université de Lyon, Lyon, 69003, France; Université Lyon 1, Lyon, 69003, France; Faculté de Médecine Lyon Est, Lyon, 69003, France. Electronic address: .